Home > Oncology > ASCO GI 2022 > Anal and Colorectal Cancer > EPOCH trial: Subgroup analyses and additional endpoints for TARE plus chemo

EPOCH trial: Subgroup analyses and additional endpoints for TARE plus chemo

Presented By
Dr William Harris, Seattle Cancer Care Alliance, WA, USA

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Conference
ASCO GI 2022
Trial
Phase 3, EPOCH
Patients with liver-dominant metastatic colorectal cancer (mCRC) benefit from the addition of trans-arterial radio-embolisation (TARE) to chemotherapy, according to subgroup analyses of the phase 3 EPOCH trial. Compared with chemotherapy alone, the combination regimen improved depth of response, objective response rate, and duration of disease control in these patients [1]. The phase 3 EPOCH trial (NCT01483027) randomised 428 patients with liver-dominant mCRC 1:1 to Y-90 glass TARE plus chemotherapy or chemotherapy alone to compare the efficacy of these therapies in the second-line [2]. The primary analysis showed improved progression-free survival (PFS), and hepatic PFS in the combination arm compared with the chemotherapy arm. Dr William Harris (Seattle Cancer Care Alliance, WA, USA) presented the results from subgroup analyses and additional endpoints of this tr...


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