Home > Gastroenterology > No benefit of additional oxaliplatin in elderly patients with mCRC

No benefit of additional oxaliplatin in elderly patients with mCRC

Presented By
Dr Tetsuya Hamaguchi, National Cancer Center, Japan

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Conference
ASCO GI 2022
Trial
Phase 3, JCOG1018, RESPECT
Elderly patients with metastatic colorectal cancer (mCRC) did not benefit from the addition of oxaliplatin to the first-line standard-of-care fluoropyrimidine plus bevacizumab treatment regimen. In addition, patients treated with additional oxaliplatin experienced a higher grade of toxicity. Therefore, the authors recommend the omission of oxaliplatin during the initial treatment of elderly patients with mCRC [1]. “Fluoropyrimidine plus oxaliplatin with bevacizumab is a first-line standard-of-care option for patients with mCRC,” said Dr Tetsuya Hamaguchi (National Cancer Center, Japan). “However, elderly patients are under-represented in clinical trials investigating potential therapies for mCRC. The JCOG1018 RESPECT study (UMIN000008866) assessed the effect of added oxaliplatin to standard-of-care regimens in elderly ...


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