Home > Gastroenterology > Prognostic impact of early oxaliplatin discontinuation in colon cancer unravelled

Prognostic impact of early oxaliplatin discontinuation in colon cancer unravelled

Presented By
Dr Claire Gallois, Université de Paris, France

Notice: Undefined index: new_doi_fields in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 138

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 138

Notice: Undefined index: new_doi_fields in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 174

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 174

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 175
Conference
ASCO GI 2022
A pooled analysis of 11 adjuvant trials showed that early treatment discontinuation (ETD) in patients with stage 3 colon cancer receiving 6 months of chemotherapy led to a reduced disease-free survival (DFS) and overall survival (OS). In contrast, early oxaliplatin discontinuation (EOD) was not associated with decreased DFS or OS if the patients had received at least 50% of the oxaliplatin cycles [1]. Dr Claire Gallois (Université de Paris, France) explained that approximately 30% of the patients with localised colon cancer discontinue their 6-month prescribed adjuvant chemotherapy early. “However, robust data on the prognostic impact of ETD or EOD is lacking.” Therefore, the current study assessed the factors associated with ETD and EOD. Moreover, the study evaluated the prognostic impact of ETD and EOD on DFS and OS. Patients were classified as ETD or EOD if they received less than 75% of the prescribed cycles of chemotherapy (i.e. FOLFOX or CAPOX) or ox...


Please login to read the full text of the article.


If you have no account yet, please register now.





Posted on