Home > Gastroenterology > TRYbeCA-1: Eryaspase + chemotherapy does not meet primary endpoint in pancreatic cancer

TRYbeCA-1: Eryaspase + chemotherapy does not meet primary endpoint in pancreatic cancer

Presented By
Prof. Pascal Hammel, Université Paris VII, France

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Conference
ASCO GI 2022
Trial
Phase 3, TRYbeCA-1
Eryaspase plus chemotherapy did not significantly outperform chemotherapy alone in the second-line treatment for patients with advanced pancreatic adenocarcinoma. However, the phase 3 TRYbeCA-1 study did suggest an advantage of additional eryaspase for resectable patients and patients with low or normal CA19-9 levels at baseline [1]. A phase 2 trial showed promising activity of eryaspase, an L-asparaginase within red blood cells, when added to FOLFOX or gemcitabine chemotherapy as a second-line therapy for patients with advanced pancreatic cancer [2]. Prof. Pascal Hammel (Université Paris VII, France) presented the results of the phase 3 TRYbeCA-1 trial (NCT03665441), in which 512 patients with stage III or IV pancreatic cancer, who underwent 1 previous line of chemotherapy, were r...


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