Home > Oncology > ASCO GU 2022 > Prostate Cancer > Addition of abiraterone to ADT/docetaxel does not increase bone loss

Addition of abiraterone to ADT/docetaxel does not increase bone loss

Presented By
Dr Guilhem Roubaud, Institut Bergonié, France

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Conference
ASCO GU 2022
Trial
Phase 3, PEACE-1
Bone mineral density decreases over time in men with de novo metastatic hormone-sensitive prostate cancer (mHSPC) treated with androgen deprivation therapy (ADT) plus docetaxel. The addition of abiraterone to ADT/docetaxel does not augment this decrease. Both ADT and next-generation hormone therapies are associated with bone loss and fracture [1]. Addition of abiraterone plus prednisone (AAP) to ADT with or without docetaxel improved overall survival in men with de novo mHSPC in the phase 3 PEACE-1 trial (NCT01957436) [2]. Dr Guilhem Roubaud (Institut Bergonié, France) presented an analysis of bone mineral density (BMD), which was planned by an amendment in the last randomised patients (n=210) to assess whether the addition of AAP increases bone loss [3]. BMD of the lumbar spine, femoral neck, and total hip were measured by dual x-ray abso...


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