Home > Oncology > ASCO GU 2022 > Penile & Testicular Cancer > Biomarkers to distinguish necrosis from teratoma before pcRPLND in testicular cancer

Biomarkers to distinguish necrosis from teratoma before pcRPLND in testicular cancer

Presented By
Dr Tim Nestler, University of Cologne, Germany

Notice: Undefined index: new_doi_fields in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 138

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 138

Notice: Undefined index: new_doi_fields in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 174

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 174

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 175
Conference
ASCO GU 2022
Post-chemotherapy retroperitoneal lymph node dissection (pcRPLND) is overtreatment for metastatic non-seminomatous testicular cancer in about half the cases. Differential expression of AGR2 and KRT19 in teratoma and necrotic tissue could be used to reliably distinguish patients with teratoma from those with necrosis and reduce overtreatment. Metastatic non-seminomatous testicular tumour patients with residual retroperitoneal tumour masses >1 cm after chemotherapy are treated with pcRPLND to remove viable tumours and teratoma, which are present in approximately 10% and 40% of cases, respectively. However, histopathology only identifies scar tissue/necrosis in up to 50%. In those patients, surgical therapy is not necessary, resulting in a relevant overtreatment. So far, no adequate pre-operative distinction between the histologies exists. Recently, the first biomarker was described with miR371a-3p in serum, which is highly specific for viable testicular ...


Please login to read the full text of the article.


If you have no account yet, please register now.





Posted on