Home > Oncology > ASCO GU 2022 > Penile & Testicular Cancer > HPV-positive and HPV-negative penile squamous cell carcinoma are molecularly distinct tumours

HPV-positive and HPV-negative penile squamous cell carcinoma are molecularly distinct tumours

Presented By
Dr Bassel Nazha, Emory University, GA, USA

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Conference
ASCO GU 2022
Penile squamous cell carcinoma is an aggressive malignancy with few effective treatment options. Genomic and molecular profiling of the tumours reveals targetable genetic alterations. Penile squamous cell carcinoma is a rare and aggressive malignancy with few treatments in the advanced setting and little success of immune checkpoint inhibitors. Around half of penile squamous cell carcinoma cases are linked to HPV infection. More insight into the landscape of somatic alterations and immune checkpoint inhibitor-related biomarkers in penile squamous cell carcinoma could establish signatures for HPV-dependent and HPV-independent oncogenesis. Therefore, Dr Bassel Nazha (Emory University, GA, USA) and colleagues retrospectively analysed data of 108 patients with penile squamous cell carcinoma [1]. Penile squamous cell carcinoma tumours were genetically and molecularly characterised using next-generation sequencing, PD-L1 expression, microsatellite instab...


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