Home > Oncology > ASCO GU 2022 > Urothelial Carcinoma > Positive efficacy and safety of N-803 plus BCG infusion in BCG-unresponsive NMIBC

Positive efficacy and safety of N-803 plus BCG infusion in BCG-unresponsive NMIBC

Presented By
Dr Sam Chang, Vanderbilt University Medical Center, TN, USA

Notice: Undefined index: new_doi_fields in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 138

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 138

Notice: Undefined index: new_doi_fields in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 174

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 174

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 175
Conference
ASCO GU 2022
Trial
Phase 3, QUILT-3.032
Intravesical Bacillus Calmette-Guerin (BCG) is active against non-muscle-invasive bladder cancer (NMIBC), but bladder cancer recurs and even progresses in a significant number of patients. The addition of N-803, a first-in-class IL-15 immunostimulatory fusion protein, to BCG was safe and had a significant clinical benefit in heavily pre-treated patients with NMIBC in the QUILT-3.032 trial. Innate immune memory is hypothesised to be an important mechanism mediating BCG therapy in NMIBC [1]. N-803 is a high-affinity IL-15 immunostimulatory fusion protein that promotes proliferation and activation of natural killer (NK) cells and CD8-positive T cells but not regulatory T cells. A phase 1b trial demonstrated that intravesical N-803 plus BCG induced complete responses in BCG-naïve NMIBC patients, without recurrences for 24 months [2]. QUILT-3.032 (NCT03022825) is...


Please login to read the full text of the article.


If you have no account yet, please register now.





Posted on