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CECR2 protein pinpointed as driver of breast cancer metastases


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Journal
Science Translational Medicine
Reuters Health - 08/02/2022 - CECR2 is an epigenetic driver of breast cancer metastasis, and inhibiting the protein prevented metastases in mouse models, researchers say. "Two findings were quite surprising," Dr. Qin Yan of Yale Cancer Center in New Haven told Reuters Health by email. "First, CECR2 had not been studied in cancer when we started to work on it. It is a gene that was amplified in patients with cat eye syndrome, with a variety of abnormalities including defects in the iris of the eye, and specific heart and kidney defects." "Second," he said, "we found that an increase of CECR2 in tumor cells elicits tumor-supporting inflammatory responses in the metastatic sites, suggesting that the host immune response could be co-opted by the tumor cells for their growth." Dr. Yan and colleagues note in Science Translational Medicine, "Emerging evidence suggests that certain epigenetic and transcriptional regulators drive cancer metastasis and could be targete...


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