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Chemoradiotherapy raises risk of thoracic vertebral fracture


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Journal
JAMA Network Open
Reuters Health - 14/09/2020 - Chemoradiotherapy for esophageal cancer increases the risk of thoracic vertebral fractures, researchers in Japan report. "Decreasing the vertebral (radiation) dose using advanced radiotherapy techniques may reduce the incidence of vertebral fractures in patients with thoracic malignancy after chemoradiotherapy," Dr. Katsuyuki Sakanaka of Kyoto University Graduate School of Medicine told Reuters Health by email. "Early intervention for osteoporosis in this population may reduce the risk of vertebral fractures." Radiotherapy for malignant neoplasms has been associated with an increased incidence of vertebral fractures, but previous studies of this association have been flawed, according to Dr. Sakanaka and colleagues. The researchers compared the incidence of vertebral fractures in patients with thoracic esophageal cancer treated by chemoradiotherapy versus those treated with endoscopy or surgery using their institutional database ...


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