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Circulating-tumor-cell dynamics have prognostic value in metastatic breast cancer


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Conference
2020 San Antonio Breast Cancer Symposium
Reuters Health - 15/12/2020 - Serial assessment of circulating tumor cells (CTCs) may help predict overall survival in women with metastatic breast cancer, according to new research. "These results provide clinical validation of CTC monitoring as an early treatment response marker in advanced breast cancer and suggest the potential for clinical utility," Dr. Wolfgang Janni of Ulm University Hospital, in Germany, said during a press briefing at the 2020 San Antonio Breast Cancer Symposium, where the findings were presented. The results are based on pooled data for more than 4,000 women with metastatic breast cancer who had baseline and follow-up CTC assessments using the U.S. Food and Drug Administration (FDA)-approved CellSearch CTC test. The median time from baseline to follow-up testing was 29 days. Changes in CTC dynamics between baseline and follow-up were associated with overall survival, Dr. Janni reported. Of the 2,961 women who were CTC-positiv...


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