Home > Oncology > De-escalation of radiotherapy for HPV-associated oropharyngeal cancer appears effective

De-escalation of radiotherapy for HPV-associated oropharyngeal cancer appears effective


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Journal
JAMA Oncology
Reuters Health - 26/01/2022 - For patients with HPV-positive oropharyngeal cancer (OPC) undergoing definitive concurrent chemoradiotherapy (CCRT), reduced radiation dose and volume to elective treatment regions yields "uncompromised" disease control with favorable toxicity, a retrospective, single-center study suggests. The data show that "major de-escalation" of radiotherapy in elective regions is "feasible while maintaining locoregional tumor control," researchers report in JAMA Oncology. Beginning in March 2017, Memorial Sloan Kettering Cancer Center in New York adopted a de-escalation strategy for patients with HPV-positive OPC undergoing CCRT, comprised of a lower radiotherapy dose to elective nodal and subclinical regions, while sparing selected negative neck, retropharyngeal, level Ib and level V nodal basins. In their retrospective study, Dr. C. Jillian Tsai and colleagues assessed the impact of these changes in 276 patients with locally advanced HPV-...


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