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DNA damage repair may be key to higher breast cancer mortality in Black women


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Journal
Therapeutic Advances in Medical Oncology
Reuters Health - 14/02/2022 - Black women's cells respond differently than whites' to damage from breast cancer and its therapy, and these molecular differences could impact mortality, researchers say. "Our results are immediately actionable for clinicians, because they suggest that Black women may not even need different therapies, just different timing for the drugs we already have," Dr. Svasti Haricharan of Sanford Burnham Prebys Medical Discovery Institute in La Jolla told Reuters Health by email. "More broadly," she said, "the findings show us that our lived experiences can absolutely change the molecular biology of our cells, and that those changes need to be considered when we're tailoring precision medicine for different patients." Recent studies identify DNA damage repair (DDR) genes as drivers of endocrine therapy resistance that contribute to poor survival among ER+ breast cancer patients, Dr. Haricharan and colleagues note in Therapeutic Advances ...


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