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Fallopian organoids promising for ovarian cancer prediction in women with BRCA mutations


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Journal
Cell Reports
Reuters Health - 05/01/2022 - Fallopian tube organoids hold the potential for predicting the development of ovarian cancer years in advance, researchers say. "There are new induced pluripotent stem cell (iPSC) technologies coming that will allow clinicians to know if a patient is highly likely to get certain types of cancer, enabling drug treatment very early - just like (a statin) to prevent plaque build-up and heart disease," Dr. Clive Svendsen of Cedars-Sinai Medical Center in Los Angeles told Reuters Health. For the current study, published in Cell Reports, Dr. Svendsen and colleagues generated iPSCs from healthy individuals and young ovarian cancer patients with germline pathogenic BRCA1 mutations (BRCA1mut). Following differentiation into fallopian tube epithelial (FTE) organoids, compared to controls, the BRCA1mut lines exhibited cellular abnormalities consistent with cancer development. Following transplantation in mice, the BRCA1mut organoids ...


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