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Gene signature predicts overall survival in women with breast cancer


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Journal
JAMA Network Open
Reuters Health - 19/10/2020 - A prognostic signature based on eight DNA-repair-related genes (DRGs) accurately predicts overall survival in women with breast cancer, researchers report. Several studies have linked various molecular biomarkers, including DRGs, with breast cancer outcomes, but there is currently no accurate prediction signature for DRGs. Dr. Zhijun Dai of Zhejiang University College of Medicine, in Hangzhou, China, and colleagues used data from the Cancer Genome Atlas and Gene Expression Omnibus databases to construct a DRG-based prognostic model to predict three- and five-year overall survival in women with breast cancer. Multivariate Cox proportional-hazards regression analysis identified eight DRGs (MDC1, RPA3, MED17, DDB2, SFPQ, XRCC4, CYP19A1, and PARP3) that were incorporated into a total risk score, with higher scores representing worse prognosis. The discriminative accuracy of the score (as assessed by area under the curve of the...


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