Home > Oncology > Little difference between molecular tests for refining thyroid-nodule diagnosis

Little difference between molecular tests for refining thyroid-nodule diagnosis


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Journal
JAMA Oncology
Reuters Health - 18/12/2020 - In patients in whom thyroid fine-needle aspiration (FNA) biopsies have failed to provide definitive guidance on nodule malignancy, the Afirma genomic-sequencing-classifier RNA test and the ThyroSeq v3 multigene-genomic-classifier DNA-RNA test are similarly predictive, according to researchers in California. As Dr. Masha Livhits of the David Geffen School of Medicine at UCLA, in Los Angeles, told Reuters Health by email, "Our findings suggest that either molecular test can be used to refine the diagnosis of indeterminate thyroid nodules - those with uncertain biopsy results." "The main clinical benefit," she added, "is that approximately half of patients with indeterminate thyroid nodules who undergo molecular testing are able to avoid surgery on the basis of a negative molecular test result." About 20% of patients who undergo FNA biopsies have nodules with indeterminate cytology, Dr. Livhits and colleagues note in JAMA Oncology. ...


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