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Margetuximab outperforms trastuzumab in advanced HER2-positive breast cancer


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Journal
JAMA Oncology
Reuters Health - 25/01/2021 - Margetuximab appears to be more effective than trastuzumab, each with chemotherapy, in women with pretreated ERBB2 (formerly HER2)-positive advanced breast cancer, which remains largely incurable, according to initial results of the SOPHIA trial. Up to one-fifth of all breast cancers are HER2-positive, and identifying new treatment options for patients in the metastatic setting represents a "serious unmet medical need," principal investigator Dr. Hope Rugo, Director of Breast Oncology and Clinical Trials Education, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, said in a news release. These findings show that margetuximab "provides improvement, for this patient population, beyond what we can achieve with trastuzumab, which is good news for patients with advanced disease," she said. Margetuximab, from MacroGenics Inc, which funded the trial, is a chimeric antibody that shares ERBB2 specific...


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