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Preop stereotactic radiotherapy tied to improved brain metastases outcomes


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Journal
Scientific Reports
Reuters Health - 28/03/2022 - In cancer patients with brain metastases, preoperative stereotactic radiotherapy (SRT) is associated with improved outcomes compared to no SRT, including a higher rate of necrosis and decreases in immunomodulatory cell populations, a small trial shows. "Some of the findings, such as increased tumor necrosis, corroborated findings from preclinical studies and stereotactic radiosurgery (SRS) series outside of the brain, but some of the findings, such as the change in immunomodulatory cell populations, were interesting and require further study," Dr. Rupesh Kotecha of the Miami Cancer Institute, Baptist Health South Florida told Reuters Health by email. Tumor samples from 22 patients (ages 35-80; two-thirds, women) who underwent dose-escalated pre-operative SRS/SRT and resection for brain metastases were included in the study, published in Scientific Reports. Samples were paired and compared with non-irradiated primary tumor samples.


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