Home > Oncology > SABCS 2021 > Basic and Translational Research > Genomic signatures of DCIS define biology and correlate with clinical outcomes

Genomic signatures of DCIS define biology and correlate with clinical outcomes

Presented By
Dr Siri Strand, Stanford University, CA, USA

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Conference
SABCS 2021
Trial
TBCRC 038;RAHBT
Based on molecular analysis of 677 ductal carcinoma in situ (DCIS) samples, several subtypes of DCIS were identified as well as an 812-gene profile predictive for recurrence. DCIS consists of a molecularly heterogeneous group of premalignant lesions, with variable risk of invasive progression. Understanding biomarkers for invasive progression could help individualise treatment recommendations based upon tumour biology and reduce overtreatment. As part of the National Cancer Institute’s Human Tumor Atlas Network (HTAN), Dr Siri Strand (Stanford University, CA, USA) and colleagues conducted comprehensive genomic analyses on 2 large DCIS case-control cohorts with a 7.1-year median follow-up (TBCRC 038 and RAHBT) [1,2]. Gene expression analysis of 677 DCIS samples from 481 patients resulted in an 812-gene profile, which was predictive for recurrence (AUC 0.72). Based on the RNA expression of all coding genes, 3 clusters were identifie...


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