Home > Oncology > SABCS 2021 > Basic and Translational Research > MAPK-pathway alterations are associated with resistance to anti-HER2 therapy

MAPK-pathway alterations are associated with resistance to anti-HER2 therapy

Presented By
Dr Emanuela Ferraro, Memorial Sloan-Kettering Cancer Center, NY, USA

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Conference
SABCS 2021
Genomic analysis of HER2-positive breast tumours identified pathways alterations associated with anti-HER2 resistance and new therapeutic vulnerabilities. Resistance to anti-human epidermal growth factor receptor 2 (HER2)-therapy is common and more insight in the molecular pathways involved, could lead to new treatment strategies. Previous research demonstrated the involvement of alterations in the PI3K-pathway in resistance to anti-HER2 therapy [1,2]. To explore the role of the mitogen-activated protein kinase (MAPK)-pathway in anti-HER2 resistance, Dr Emanuela Ferraro (Memorial Sloan-Kettering Cancer Center, NY, USA) and colleagues performed next generation sequencing on 733 HER2-amplified tumours (385 primary, 348 metastatic) from patients with advanced HER2-positive breast cancer. Frequency of MAPK-pathway alterations was 9.8% in primary tumours and 15.6% in metastatic tumours [3,4]. Of note: frequency of PI3K-pathway alterati...


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