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One in 7 breast cancers detected during screening are overdiagnosed

Presented By
Dr Marc Ryers , Duke University Medical Center, NC, USA

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Conference
SABCS 2021
A new model, based on data from the Breast Cancer Surveillance Consortium (BCSC), suggests that overdiagnosis of screen-detected breast cancer is less frequent than estimated from excess-incidence studies. However, the model also takes indolent tumours into account and produced a higher estimate than previous models that didn’t consider this factor. Breast cancer screening is subject to overdiagnosis, which is the mammographic detection of cancers that would not become symptomatic or otherwise cause harm in the absence of screening. Estimates of overdiagnosis based on excess incidence are prone to bias, and estimates based on models have been criticised for not explicitly accommodating indolent tumours. Dr Marc Ryers (Duke University Medical Center, NC, USA) and colleagues developed a model that accounts for the transition from healthy to preclinical and clinical disease, while allowing for a fraction of indolent preclinical tumours [1]. Based on...


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