Home > Oncology > SABCS 2021 > HR-positive/HER2-negative Breast Cancer > Premenopausal women benefit from adjuvant chemotherapy next to endocrine therapy

Premenopausal women benefit from adjuvant chemotherapy next to endocrine therapy

Presented By
Dr Kevin Kalinsky, Emory University Winship Cancer Institute, GA, USA

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Conference
SABCS 2021
Trial
Phase 3, RxPONDER
The phase 3 RxPONDER trial evaluated the benefit of adjuvant chemotherapy followed by endocrine therapy in women with hormone receptor (HR)-positive/HER2-negative, early-stage breast cancer and 1–3 positive nodes. Updated results confirmed that the menopausal status makes the difference in this population. The RxPONDER trial (NCT01272037) evaluated the benefit of chemotherapy followed by endocrine therapy versus endocrine therapy alone in patients who had an Oncotype DX Recurrence Score (RS) <25. A previous analysis of RxPONDER after a median follow-up of 5 years reported that invasive disease-free survival (IDFS) and distant disease-free survival (DDFS) differed by menopausal status [1]. In the current study, Dr Kevin Kalinsky (Emory University Winship Cancer Institute, GA, USA) reported updates on IDFS and DDFS wi...


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