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Should tomosynthesis replace mammography?


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Journal
The Lancet Oncology
Reuters Health - 20/04/2022 - Digital breast tomosynthesis plus synthesized two-dimensional mammography finds significantly more invasive breast cancers than digital mammography alone, according to results of the TOSYMA study. Writing in The Lancet Oncology, the study team notes that 2D full-field digital mammography is the current standard of breast-cancer screening. "Digital breast tomosynthesis generates pseudo-three dimensional datasets of the breast from which synthesized 2D (s2D) mammograms can be reconstructed. This innovative approach reduces the likelihood of overlapping breast tissues that can conceal features of malignancy," they explain. TOSYMA was a multicenter, randomized, open-label superiority trial embedded in the German population-wide mammography screening program. Over roughly two and a half years, nearly 100,000 women were randomly assigned (1:1) to digital breast tomosynthesis plus s2D mammography or digital mammography alone....


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