Home > Oncology > Trispecific antibody activates CD 4 cells to curb breast cancer growth in mice

Trispecific antibody activates CD 4 cells to curb breast cancer growth in mice


Notice: Undefined index: new_doi_fields in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 138

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 138

Notice: Undefined index: new_doi_fields in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 174

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 174

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 175
Journal
Nature
Reuters Health - 10/03/2022 - A novel "trispecific" antibody to HER2, CD3 and CD28 inhibited breast cancer growth in mice via a mechanism involving CD4 cells, researchers say. "Immunotherapies show remarkable efficacy in treating cancers, but they work in only a fraction of cases," Dr. Gary Nabel of ModeX Therapeutics in Natick, Massachusetts told Reuters Health by email. "A next generation of immune therapies uses new technology, trispecific antibodies, and is showing promise preclinically in directing immune cells to tumors, where they can block cancer cell proliferation at the same time they stimulate the immune system to kill malignancies." Dr. Nabel, the senior author of a report in Nature, added that clinical trials of the trispecific antibody SAR443216 are underway now, sponsored by Sanofi. Dr. Valeria Fantin, Head of Oncology Research at Sanofi, also commented in an email to Reuters Health. "Until now, it was widely believed that CD8 T cells were the ...


Please login to read the full text of the article.


If you have no account yet, please register now.





Posted on