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Distinct changes in lung microbiome precede clinical diagnosis of lung cancer

Presented By
Ms Erin Marshall, University of British Columbia, Canada

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Conference
ERS 2020
The comparison of the airway microbiome of cancer patients, incident-cancer patients, and people without cancer demonstrated that a specific shift in microbiota species preceded cancer development [1]. The tumour microenvironment (TME) has demonstrated importance to lung cancer biology. In particular, the presence of specific bacterial species in the gut has been associated with a response to checkpoint blockade in lung cancers [2]. It is possible that, in addition to their immune modulatory effect, commensal microbes may also secrete modulators or generate metabolites to potentiate tumour cells sensitivity to apoptosis induction and, thereby, rendering cancer patient response to ICI immunotherapy [3]. Nowadays, it has been shown that bacterial communities are different in the tumour compared with the surrounding non-malignant cells. One of the reasons for the poor survival in lung cancer is late disease detection. The presence of certain bacteria in the a...


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