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ICS plus LABA improves lung function in school-age preemie children


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Journal
JAMA Pediatrics
Reuters Health - 22/12/2021 -  Combining inhaled corticosteroids (ICS) with long-acting beta-2-receptor agonists (LABA) improves lung function in school-age children who were born prematurely, according to results of a randomized controlled trial. "Although it has been known for several decades that prematurity is associated with low lung function in childhood and adulthood, the treatment for this decreased lung function has remained largely unknown," said Dr. Sailesh Kotecha, a professor at Cardiff University in Wales. "Our clinical trial addressed this gap in knowledge," he told Reuters Health by email. "The trial showed that inhaled steroids improved percent predicted FEV1 by nearly 8%, but that the combination of inhaled corticosteroids with LABA was superior, improving FEV1 by 14% after 12 weeks compared to placebo inhalers." He added, "It is now reasonable to treat preterm-born children who have respiratory symptoms or decreased lung function with a tri...


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