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No support for adjuvant radiation in resected N2 non-small-cell lung cancer


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Journal
The Lancet Oncology
Reuters Health - 31/12/2021 - Results of the Lung Adjuvant Radiotherapy Trial (Lung ART) do not support the use of postoperative radiotherapy (PORT) in patients with completely resected (R0) N2 non-small-cell lung cancer (NSCLC). "Lung ART provides robust evidence that 3D conformal PORT cannot generally be recommended as part of the standard of care in patients with resected stage IIIA N2 NSCLC. Because mediastinal relapse was substantially reduced by radiotherapy, other analyses are warranted to identify the patients for whom PORT could be used," researchers write in The Lancet Oncology. For more than two decades, the role of PORT has been "controversial in patients with completely resected N2 NSCLC, because no contemporary clinical trials with adequate staging and treatment were available," say the authors of a linked comment. Therefore, results of Lung ART trial have been "eagerly awaited" and the study team should be "congratulated for completing this cha...


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