Home > Rheumatology > ACR 2021 > SLE Treatment: What Is New > Iberdomide: an upcoming new treatment possibility in lupus erythematosus

Iberdomide: an upcoming new treatment possibility in lupus erythematosus

Presented By
Prof. Joan Merrill, Oklahoma Medical Research Foundation, OK, USA

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Conference
ACR 2021
Trial
Phase 2
In an extension trial after the blinded phase 2 evaluation, iberdomide showed lasting benefits as a therapeutic agent for systemic lupus erythematosus (SLE). Safety assessments up to 1 year were reassuring. “Iberdomide is a high-affinity cereblon ligand that promotes degradation of 2 transcription factors: Ikaros and Aiolos. These factors are involved in immune-cell development, homeostasis, and genetic variants associated with risk for lupus,” Prof. Joan Merrill (Oklahoma Medical Research Foundation, OK, USA), explained the properties of the study drug [1]. Gene polymorphisms of these transcription factors are associated with the risk of SLE and these transcription factors are overexpressed in the blood cells of patients with SLE [2–4]. In a previously published phase 2, randomised-controlled trial, oral iberdomide has been investigated for efficacy and safety in the treatment of SLE (


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