Home > Rheumatology > ACR 2021 > Spotlight on Rheumatoid Arthritis > Pre-existing heart failure affects safety of hydroxychloroquine in RA patients

Pre-existing heart failure affects safety of hydroxychloroquine in RA patients

Presented By
Dr Elvira D’Andrea, Brigham and Women’s Hospital, MA, USA

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Conference
ACR 2021
Comparing methotrexate and hydroxychloroquine therapy for rheumatoid arthritis (RA) resulted in similar results for severe cardiovascular events or sudden cardiac death/ventricular arrhythmia. In case of a concomitant heart failure diagnosis, methotrexate appears to be a safer option in terms of mortality and cardiovascular events. “In the US, hydroxychloroquine is commonly used as a first-line treatment in patients with RA, while methotrexate is the recommended first-line disease-modifying antirheumatic drug (DMARD),” Dr Elvira D’Andrea (Brigham and Women’s Hospital, MA, USA) stated [1]. In the wake of assessments on hydroxychloroquine use in COVID-19 patients, concerns regarding cardiovascular safety have been raised [2]. “We conducted a comprehensive cardiovascular safety evaluation of hydroxychloroquine compared with methotrexate in patients with RA,” Dr D’Andrea explained the aim of the presented research [1]. Data from Medicare linked to the N...


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