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Allopurinol treatment for gout appears safe in kidney patients


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Journal
Annals of Internal Medicine
Reuters Health - 25/01/2022 - For patients with gout and chronic kidney disease (CKD), treatment with allopurinol to achieve a target serum urate (SU) level does not increase the risk of dying, new research indicates. In a large review of health records, "neither allopurinol initiation, nor achieving target SU level with allopurinol, nor allopurinol dose escalation were associated with an increased risk for death in patients with gout and concurrent CKD," the study team reports in Annals of Internal Medicine. CKD is a common comorbidity in patients with gout and the cornerstone of gout management is urate-lowering therapy, typically with allopurinol. "Allopurinol treatment is started at low dose, increased over weeks-months to achieve the target serum urate level, and continued indefinitely," senior author Dr. Yuqing Zhang of Massachusetts General Hospital and Harvard Medical School, in Boston, told Reuters Health by email. "Two recent randomized contr...


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