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COVID-19 vaccines effective in younger patients with childhood-onset rheumatic diseases


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Journal
Rheumatology
Reuters Health - 17/03/2022 - A two-dose regimen of COVID-19 mRNA vaccines elicited a robust humoral neutralization response in almost all adolescents and young adults with childhood-onset rheumatic diseases in a new study from Singapore. Methotrexate and mycophenolate-mofetil significantly decreased immunogenicity after the first vaccination, although not after the second dose, researchers report in Rheumatology. No major adverse events were noted following vaccination, and the main adverse effects were self-resolving injection-site reactions with pain and swelling. Disease flare was seen in 4.4% of patients after the second mRNA vaccine dose, report Dr. Thaschawee Arkachaisri of KK Women's and Children's Hospital and colleagues. "Our findings serve to reassure the community that after two vaccine doses, humoral immune response is excellent in the majority of these children," Dr. Arkachaisri told Reuters Health by email. He said that barring other med...


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