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RA: Several risk factors identified for incident dementia

Presented By
Dr Elena Myasoedova, Mayo Clinic, USA
EULAR 2022
Cohort study
Data from a cohort study detected various factors that were linked to a risk amplification for the development of dementia in patients with rheumatoid arthritis (RA). Among those, swelling of large joints, hypertension, cardiovascular disease, and depression led to an about 2-fold risk. A population-based inception cohort study investigated potential risk factors for dementia in patients with RA [1]. The study included 886 patients ≥50 years who resided in Minnesota, USA, and were diagnosed with RA between 1980 and 2014. Follow-up was performed until the end of 2019. For the attribution of incident dementia, at least 2 ICD codes for dementia had to be present ≥30 days apart. Two different Cox proportional hazard models were fitted with model 1 adjusting for age, sex, and year of RA incidence. The other model also included cardiovascular (CV) risk factors as well as any CV disease. The mean age of the cohort was 65 years, nearly 2 thirds were women, ...

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