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Methotrexate plus leflunomide a treatment option for psoriatic arthritis


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Journal
The Lancet Rheumatology
Reuters Health - 18/03/2022 - In patients with psoriatic arthritis, combination therapy with methotrexate plus leflunomide is more effective than methotrexate alone, but less well tolerated, a single center, randomized, placebo-controlled trial showed. "Our findings increase the knowledge on the seemingly superior efficacy of leflunomide and methotrexate combination therapy versus methotrexate monotherapy in psoriatic arthritis," Dr. Michelle Mulder of Sint Maartenskliniek, Nijmegen in the Netherlands told Reuters Health by email. "Clinicians might consider using this combination in either a step-down or -up approach depending on the situation." "Although our hypothesis was that the addition of leflunomide to methotrexate would be superior to methotrexate monotherapy, the difference in effectiveness still surprised us," she said. "Particularly striking was that (although) a large percentage of the included patients had limited oligoarticular disease, we still found ...


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