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No elevated risk for influenza AE in tofacitinib-treated RA patients


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Conference
ACR 2020
A posthoc analysis covering 14-15 influenza seasons revealed that influenza adverse events were similar between rheumatoid arthritis patients treated with tofacitinib, adalimumab, methotrexate, and placebo. A previous study has shown that rheumatoid arthritis (RA) is associated with an increased incidence of seasonal influenza and its complications [1]. The COVID-19 pandemic highlights the need to understand how RA itself and its therapy can influence acute respiratory RNA viral infections. To evaluate how this risk is influenced by therapy with tofacitinib, a posthoc analysis from 21 phase 1–3b/4 studies and 2 open-label, long-term extension studies from 2005-2019 with RA patients was performed, which covered a total of 14–15 influenza seasons [2]. Data was analysed from 2 cohorts: in the phase 2–3b/4 cohort, patients received tofacitinib as monotherapy or with background DMARDs (adalimumab or methotrexate). In the overall cohort, patients received ≥1 dos...


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