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Daprodustat an oral alternative to ESAs in kidney patients starting dialysis


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Journal
JAMA Internal Medicine
Reuters Health - 04/04/2022 - Oral daprodustat works as well as injected darbepoetin alfa in the treatment of anemia in patients with chronic kidney disease (CKD) starting dialysis, according to results of the ASCEND-ID trial. The results, online in JAMA Internal Medicine, build on results from the ASCEND-ND and ASCEND-D trials published last year involving patients with anemia due to CKD in both the non-dialysis and dialysis settings. Daprodustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor being developed by GlaxoSmithKline, which funded the study. The ASCEND-ID trial enrolled 312 adults (median age, 55 years) with advanced CKD who were planning to start dialysis within six weeks or who recently started receiving hemodialysis or peritoneal dialysis; 157 were randomly assigned to oral daily daprodustat and 155 to subcutaneous/intravenous darbepoetin alfa. Daprodustat was noninferior to darbepoetin alfa in this patient population, r...


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