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Doctors successfully transplant pig kidney into brain-dead man

American Journal of Transplantation
Reuters Health - 27/01/2022 - It's been an exciting month for transplant medicine. Earlier this month, a team at the University of Maryland announced the successful transplant of a genetically modified pig's heart into a man with terminal cancer. This week, a team from the University of Alabama at Birmingham (UAB) says they successfully transplanted two kidneys from a genetically modified pig into a brain-dead man after his native kidneys were removed. The transplanted kidneys filtered blood and produced variable amounts of urine, although creatinine clearance did not recover. Longitudinal biopsies revealed thrombotic microangiopathy that did not progress in severity. "Whether renal recovery was impacted by the milieu of brain death and/or microvascular injury remains unknown," the research team reports in the American Journal of Transplantation. No chimerism or transmission of porcine retroviruses was detected and the pig kidneys were not immed...

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