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Mineralocorticoid-receptor antagonists appear to protect against kidney failure in CKD


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Journal
Hypertension
Reuters Health - 03/02/2022 - For patients with chronic kidney disease (CKD), treatment with a mineralocorticoid-receptor antagonist (MRA) appears to protect against kidney failure requiring renal replacement therapy, according to a retrospective cohort study. MRA users showed a "better renal prognosis" across various CKD subgroups in a real-world CKD population, Dr. Tatsufumi Oka with Osaka University and colleagues report in Hypertension. Preventing kidney failure with replacement therapy is "an ultimate treatment goal" for patients with CKD, they note in their paper. "Notably, there has been a lack of real-world evidence examining the association between MRA use and hard renal outcomes, including kidney failure with replacement therapy," they point out. To investigate, Dr. Oka and colleagues took a look back at 3,195 adults with CKD treated at Osaka University Hospital from 2005 to 2018. At baseline, their median age was 66 years and median estimate...


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