Warning: file_get_contents(https://multipass.sense-studios.com/check_token/-1?url=%2Funcategorized%2Flow-early-pasi-response-could-predict-favourable-outcomes-for-psoriasis-patients-on-biologics%2F&agent=CCBot%2F2.0+%28https%3A%2F%2Fcommoncrawl.org%2Ffaq%2F%29&name=dev.mc.sense-studios.com&ip=34.225.194.102&categories=Uncategorized): failed to open stream: HTTP request failed! HTTP/1.1 500 Internal Server Error in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/template-parts/header-tokenaccess.php on line 114

Notice: Trying to get property 'status' of non-object in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/template-parts/header-tokenaccess.php on line 117

Notice: Trying to get property 'access_type' of non-object in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/template-parts/header-tokenaccess.php on line 123
Low early PASI response could predict favourable outcomes for psoriasis patients on biologics - Medical Conferences

Home > Low early PASI response could predict favourable outcomes for psoriasis patients on biologics

Low early PASI response could predict favourable outcomes for psoriasis patients on biologics

Presented By
Dr Nikolai Dyrberg, University of Copenhagen, Denmark

Notice: Undefined index: new_doi_fields in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 138

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 138

Notice: Undefined index: new_doi_fields in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 174

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 174

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 175
Conference
EADV 2020
Greater treatment compliance and fewer flare-ups were seen in bio-naïve patients with psoriasis treated with biologic therapy who had an early Psoriasis Area and Severity Index (PASI) score of ≤2.

Dr Nikolai Dyrberg (University of Copenhagen, Denmark) presented the findings of a Danish nationwide study that followed 1,684 patients with psoriasis receiving biologic therapy for the first time [1]. Median response time was 112 days. At baseline, 746 participants had a PASI of 0; 485 had a PASI between 0 and ≤2; 246 had a PASI >2 but ≤4; and 207 had a PASI >4. Defining a flare-up as any increase of their PASI score by ≥3, 42.8% of patients experienced flare-ups. However, patients with a lower PASI score during the first 6 months of treatment experienced longer flare-free periods. These outcomes were independent of drug, sex, age, weight, and use of methotrexate.

Dr Dyrberg’s team documented a more stable disease course, lower risk of flares, and decreased treatment discontinuation in bio-naïve patients with psoriasis treated with biologics who had a low early PASI response. Given these results, they recommend a treatment target of PASI ≤2 in the first year of treatment in this patient group.

 


    1. Dyrberg Loft N. Risk of disease flares during first biologic therapy among patients with stable and controlled psoriasis: A Danish Nationwide Study. P1331, EADV Virtual Congres, 29-31 October 2020.




Posted on